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2-OH-NPA Structure

2-OH-NPA is a chemical compound that acts as a potent and selective agonist for the D2 dopamine receptor. Its full chemical name is 2-hydroxy-4-(4-naphthylpiperazine-1-yl)butanamide, and it is used primarily in scientific research to study the function of the D2 receptor in the brain. The D2 receptor is one of five subtypes of the dopamine receptor that are critical for many neurological processes, including motor control, motivation, and reward, as well as the regulation of the release of various hormones.

Pharmacology[edit | edit source]

2-OH-NPA exhibits high affinity and selectivity for the D2 receptor, making it a valuable tool for neuroscientists studying dopaminergic signaling. By activating the D2 receptor, 2-OH-NPA can mimic the effects of dopamine, a key neurotransmitter in the brain. This has implications for understanding diseases characterized by dysregulated dopamine signaling, such as Parkinson's disease, schizophrenia, and drug addiction.

Research Applications[edit | edit source]

In research, 2-OH-NPA is used to investigate the role of D2 receptors in behavior, cognition, and neurological diseases. It helps in elucidating the mechanisms by which D2 receptor activation influences these processes and conditions. For example, studies using 2-OH-NPA can help clarify how alterations in D2 receptor function contribute to the symptoms of schizophrenia or the motor deficits observed in Parkinson's disease.

Chemical Properties[edit | edit source]

2-OH-NPA is a synthetic compound that requires careful handling and storage. It is typically used in laboratory settings rather than in clinical applications due to its potent pharmacological activity and the specificity of its action.

Safety and Regulation[edit | edit source]

As a research chemical, 2-OH-NPA is subject to regulations governing the use of potentially hazardous substances in the laboratory. Researchers must follow appropriate safety protocols, including the use of personal protective equipment and proper waste disposal methods, to minimize risks associated with its handling.

Conclusion[edit | edit source]

2-OH-NPA serves as an important tool in the field of neuroscience, offering insights into the complex role of D2 receptors in the brain. Its selective action on these receptors aids in the development of targeted therapies for neurological and psychiatric disorders. However, its use is confined to research settings due to the need for further studies to establish its safety and efficacy in clinical applications.

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Contributors: Prab R. Tumpati, MD