Spiperone

Spiperone is a butyrophenone based antipsychotic and research chemical that was first introduced by Janssen Pharmaceutica in 1978. It is most commonly used in scientific research and has been shown to be particularly useful in the study of dopamine and serotonin receptors in the brain.

Chemical Structure and Properties

Spiperone is a synthetic compound of the butyrophenone class. It is structurally related to other butyrophenone antipsychotics such as haloperidol and droperidol. The chemical formula of spiperone is C23H26FN3O2 and its molecular weight is 395.47 g/mol.

Pharmacology

Spiperone acts as an antagonist at both dopamine D2 and D3 receptors, and serotonin 5-HT2A and 5-HT1A receptors. It has high affinity for these receptors and is often used in research to label and study them. Spiperone has been used in the development of radioligands for the study of dopamine and serotonin receptors in the brain.

Clinical Use

While spiperone is not typically used in clinical practice due to its side effects, it has been used in research settings to study various neurological and psychiatric disorders. These include schizophrenia, Parkinson's disease, and depression.

Side Effects

Like other butyrophenone antipsychotics, spiperone can cause a range of side effects. These can include extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome. Due to these potential side effects, spiperone is not commonly used in clinical practice.

See Also

• Butyrophenone
• Antipsychotic
• Dopamine
• Serotonin
• Haloperidol
• Droperidol

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