Desmethoxyfallypride

Desmethoxyfallypride is a radioligand used in positron emission tomography (PET) imaging. It is a derivative of fallypride with higher selectivity for dopamine D2/D3 receptors.

Chemistry

Desmethoxyfallypride is a benzamide derivative, similar to its parent compound fallypride. It is synthesized by removing the methoxy group from the 7-position of fallypride.

Pharmacology

Desmethoxyfallypride has high affinity for dopamine D2/D3 receptors, with a Ki value of 0.5 nM. It is used in PET imaging to study the distribution and density of these receptors in the brain.

Clinical Use

In clinical research, desmethoxyfallypride has been used to study various neurological and psychiatric disorders, including schizophrenia, Parkinson's disease, and drug addiction. It has also been used in research to study the effects of various drugs on dopamine receptor occupancy.

See Also

• Fallypride
• Dopamine receptor
• Positron emission tomography

Desmethoxyfallypride Resources
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