Desmethoxyfallypride
Chemical compound
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Desmethoxyfallypride is a chemical compound that is used in medical research and pharmacology. It is a derivative of fallypride, which is a dopamine D2/D3 receptor antagonist. Desmethoxyfallypride is primarily utilized in positron emission tomography (PET) imaging to study the dopamine receptor system in the brain.
Chemical Properties[edit | edit source]
Desmethoxyfallypride has a chemical structure similar to that of fallypride, but it lacks a methoxy group. This slight modification can affect its binding affinity and selectivity for dopamine receptors. The chemical formula of desmethoxyfallypride is C18H25Cl2N3O2.
Applications in Research[edit | edit source]
Desmethoxyfallypride is used in neuroscience research to investigate the role of dopamine receptors in various neurological disorders such as schizophrenia, Parkinson's disease, and addiction. By using PET imaging, researchers can visualize and quantify the distribution of dopamine receptors in the brain, which can provide insights into the pathophysiology of these disorders.
Pharmacology[edit | edit source]
As a dopamine D2/D3 receptor antagonist, desmethoxyfallypride binds to these receptors and inhibits their activity. This property makes it useful in studying the dopaminergic system, which is implicated in many psychiatric and neurological conditions. The pharmacokinetics of desmethoxyfallypride, including its absorption, distribution, metabolism, and excretion, are important for understanding its behavior in the body and optimizing its use in research.
Safety and Handling[edit | edit source]
As with many research chemicals, proper safety protocols should be followed when handling desmethoxyfallypride. This includes using appropriate personal protective equipment (PPE) and working in a controlled environment to prevent exposure and contamination.
See Also[edit | edit source]
- Fallypride
- Dopamine receptor
- Positron emission tomography
- Schizophrenia
- Parkinson's disease
- Addiction
References[edit | edit source]
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