Dextrallorphan
Dextrallorphan (DXO) is an opioid and the main metabolite of dextromethorphan (DXM). It is produced in the body following the administration of dextromethorphan and is responsible for part of the parent drug's antitussive effects. Dextrallorphan is also an NMDA receptor antagonist and contributes to the psychoactive effects of dextromethorphan.
Pharmacology[edit | edit source]
Dextrallorphan acts as a non-competitive NMDA receptor antagonist and an opioid receptor agonist. It is the main active metabolite of dextromethorphan and is thought to contribute significantly to its parent drug's antitussive effects. Dextrallorphan has also been found to possess analgesic properties.
Metabolism[edit | edit source]
Dextrallorphan is produced in the body from dextromethorphan by the enzyme CYP2D6. The rate of this conversion is highly variable, as it is influenced by individual differences in CYP2D6 activity. This variability can significantly affect the intensity and duration of dextromethorphan's effects.
Psychoactive effects[edit | edit source]
In addition to its antitussive and analgesic effects, dextrallorphan is also known for its psychoactive properties. It can induce a state of dissociation and has been used recreationally for this purpose. The psychoactive effects of dextrallorphan are thought to be primarily due to its action as an NMDA receptor antagonist.
See also[edit | edit source]
| Dextrallorphan Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
