Dextrallorphan

Dextrallorphan (DXO) is an opioid and the main metabolite of dextromethorphan (DXM). It is produced in the body following the administration of dextromethorphan and is responsible for part of the parent drug's antitussive effects. Dextrallorphan is also an NMDA receptor antagonist and contributes to the psychoactive effects of dextromethorphan.

Pharmacology

Dextrallorphan acts as a non-competitive NMDA receptor antagonist and an opioid receptor agonist. It is the main active metabolite of dextromethorphan and is thought to contribute significantly to its parent drug's antitussive effects. Dextrallorphan has also been found to possess analgesic properties.

Metabolism

Dextrallorphan is produced in the body from dextromethorphan by the enzyme CYP2D6. The rate of this conversion is highly variable, as it is influenced by individual differences in CYP2D6 activity. This variability can significantly affect the intensity and duration of dextromethorphan's effects.

Psychoactive effects

In addition to its antitussive and analgesic effects, dextrallorphan is also known for its psychoactive properties. It can induce a state of dissociation and has been used recreationally for this purpose. The psychoactive effects of dextrallorphan are thought to be primarily due to its action as an NMDA receptor antagonist.

See also

• Dextromethorphan
• Opioid
• NMDA receptor antagonist

Dextrallorphan Resources
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