4-PPBP
4-PPBP is a compound that is used in scientific research. It acts as a potent and selective sigma-1 receptor agonist, and has been used to develop radiolabelled ligands for mapping the distribution of sigma-1 receptors in the brain.
Chemistry[edit | edit source]
4-PPBP is a synthetic compound that belongs to the class of phenylpiperazines. It is structurally related to other phenylpiperazine derivatives that are known to have biological activity, such as the antidepressant buspirone and the antipsychotic ziprasidone.
Pharmacology[edit | edit source]
The primary pharmacological action of 4-PPBP is as an agonist at the sigma-1 receptor. This receptor is a type of protein that is found in the brain and other tissues, and is involved in a variety of physiological processes. Activation of the sigma-1 receptor by 4-PPBP can have a number of effects, depending on the specific context and the other neurotransmitters that are present.
Research uses[edit | edit source]
One of the main uses of 4-PPBP is in the development of radiolabelled ligands for mapping the distribution of sigma-1 receptors in the brain. These ligands can be used in PET scans to visualize the location and density of sigma-1 receptors, which can provide valuable information about the role of these receptors in various neurological and psychiatric disorders.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
