PB-28

PB-28 is a sigma receptor agonist, with a strong selectivity for the sigma-2 receptor. It is used in scientific research.

Pharmacology

PB-28 is a potent sigma receptor agonist, with a strong selectivity for the sigma-2 receptor. It has a Ki of 0.68 nM at the sigma-2 receptor, and 137 nM at the sigma-1 receptor. PB-28 is an antagonist at the alpha-1 adrenergic receptor and the 5-HT2A receptor, but with much lower affinity than for the sigma-2 receptor.

Chemistry

PB-28 is a cyclohexylpiperazine derivative, structurally related to the drug clozapine.

Research

PB-28 has been studied for its potential use in the treatment of cancer, due to its ability to trigger apoptosis in tumor cells.

See also

• Sigma-2 receptor
• Sigma-1 receptor
• Cyclohexylpiperazine
• Clozapine

References

PB-28 Resources
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