Noribogaine

Noribogaine is a psychoactive compound that is derived from ibogaine. It is the primary metabolite of ibogaine and is thought to play a significant role in ibogaine's anti-addictive effects. Noribogaine is also a potent serotonin reuptake inhibitor, and promotes the release of neurotrophic factors such as BDNF, which may contribute to its therapeutic effects.

Pharmacology

Noribogaine is a potent serotonin reuptake inhibitor, and has also been found to act as a moderate κ-opioid receptor agonist and weak μ-opioid receptor agonist. It is not known whether noribogaine is a prodrug that is converted into ibogaine in the body, or whether it has its own independent effects.

Therapeutic uses

Noribogaine is primarily used in the treatment of substance use disorders, particularly opioid addiction. It has been found to reduce drug cravings and withdrawal symptoms in animal studies, and anecdotal reports suggest that it may have similar effects in humans. However, clinical trials are needed to confirm these findings.

Safety

The safety of noribogaine is not well-studied. It is known to have a similar side effect profile to ibogaine, which can cause serious heart problems and even death in rare cases. Therefore, noribogaine should only be used under medical supervision.

See also

• Ibogaine
• Psychoactive drug
• Serotonin reuptake inhibitor
• Substance use disorder

Noribogaine Resources
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