5-MeO-DMT

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5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) is a naturally occurring psychedelic of the tryptamine class. It is found in a variety of plant species and in the venom of the Colorado River toad (Incilius alvarius). It is structurally related to DMT (N,N-dimethyltryptamine) and bufotenin (5-HO-DMT).

Chemistry

5-MeO-DMT is a tryptamine derivative, featuring a methoxy group at the fifth position of the indole ring. Its chemical formula is C₁₃H₁₈N₂O, and it has a molecular weight of 218.30 g/mol. The compound is typically a white to off-white crystalline solid.

Pharmacology

5-MeO-DMT acts as a serotonin receptor agonist, primarily at the 5-HT2A receptor. It is known for its rapid onset and short duration of action, typically lasting between 30 to 45 minutes when smoked or vaporized. The effects are often described as intense and can include hallucinations, euphoria, and mystical experiences.

Usage

5-MeO-DMT has been used in shamanic practices and modern psychedelic therapy. It is often vaporized or smoked, but it can also be insufflated or taken orally with a monoamine oxidase inhibitor (MAOI).

Legal Status

The legal status of 5-MeO-DMT varies by country. In the United States, it is classified as a Schedule I controlled substance under the Controlled Substances Act. In other countries, it may be regulated differently or remain unscheduled.

Safety and Risks

The use of 5-MeO-DMT carries potential risks, including psychological distress, tachycardia, and hypertension. It is advised to use the substance in a controlled setting with proper harm reduction practices.

See also

• DMT
• Bufotenin
• Psychedelic therapy
• Serotonin receptor