JWH-015

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JWH-015 is a synthetic cannabinoid from the naphthoylindole family. It acts as a selective agonist for the cannabinoid receptor CB2, with a Ki of 13.8 nM and selectivity of approximately 27.8 times over the CB1 receptor.

Pharmacology

JWH-015 is known for its high affinity for the CB2 receptor, which is primarily found in the immune system. This selectivity makes it a subject of interest for research into anti-inflammatory and immunomodulatory effects. Unlike many other synthetic cannabinoids, JWH-015 has a lower affinity for the CB1 receptor, which is predominantly located in the central nervous system.

Chemical Structure

The chemical structure of JWH-015 includes a naphthalene ring attached to a methanone group, which is further connected to a 2-methyl-1-propylindole moiety. This structure is similar to other compounds in the naphthoylindole family, such as JWH-018 and JWH-073.

Legal Status

The legal status of JWH-015 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In others, it remains legal for research purposes.

Research Applications

JWH-015 is primarily used in scientific research to study the effects of selective CB2 receptor activation. It has been investigated for its potential therapeutic applications in conditions such as autoimmune diseases, inflammatory disorders, and pain management.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• JWH-073