N1-Methyl-lysergic acid diethylamide

N1-Methyl-lysergic acid diethylamide (N1-Methyl-LSD), also known as ALD-52, is a chemical analogue of lysergic acid diethylamide (LSD). It was originally discovered by Albert Hofmann, the Swiss chemist who first synthesized LSD, in his research on LSD analogues.

Chemistry

N1-Methyl-LSD is a semi-synthetic molecule of the lysergamide class. The structure of N1-Methyl-LSD is similar to that of LSD, with an N1-methyl group added to the indole ring. This makes it a structural analogue of LSD, with the N1-methyl group being the only difference between the two molecules.

Pharmacology

The pharmacology of N1-Methyl-LSD is not fully understood. However, it is known to act as a serotonin receptor agonist, similar to other lysergamides. It is believed to produce its psychedelic effects by binding to the 5-HT2A receptor, which is found in the brain.

Effects

The effects of N1-Methyl-LSD are reported to be similar to those of LSD. These can include visual hallucinations, altered thinking processes, closed and open eye visuals, synesthesia, an altered sense of time, and spiritual experiences. The effects typically last for 6-12 hours, depending on the dose and individual metabolism.

Legal Status

The legal status of N1-Methyl-LSD varies by country. In the United States, it is classified as a Schedule I controlled substance, making it illegal to manufacture, buy, possess, or distribute without a license from the Drug Enforcement Administration (DEA).

See Also

• Lysergic acid diethylamide
• Psychedelic drug
• Serotonin receptor