Diethyltryptamine

Diethyltryptamine (DET) is a psychedelic drug belonging to the tryptamine family. It is historically known for its psychoactive properties and is classified as a hallucinogen.

Chemistry

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Chemical structure of Diethyltryptamine

Diethyltryptamine is a synthetic compound of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. DET is substituted at R1 and R2 of its structure with ethyl groups. It is analogous to DMT where two methyl groups are replaced by ethyl groups.

Pharmacology

DET's psychoactive effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects

The effects of DET are similar to other psychedelic tryptamines. They can be broken down into several components which progressively intensify proportional to dosage. These include:

• Physical effects: The physical effects of DET can include pupil dilation, increased heart rate, and nausea.
• Visual effects: DET can induce a range of visual effects, such as enhanced colors, visual acuity, and pattern recognition.
• Cognitive effects: The cognitive effects of DET are described by many as deep introspection, euphoria, time distortion, and immersion enhancement.

Legal Status

The legal status of DET varies from country to country. In the United States, it is classified as a Schedule I controlled substance, making it illegal to manufacture, buy, possess, or distribute without a license.

See Also

• Tryptamine
• Psychedelic drug
• Hallucinogen

References

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