JWH-164

Chemical structure of JWH-164

JWH-164 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Properties

JWH-164 is characterized by its chemical structure, which includes a naphthoyl group attached to an indole core. This structure is similar to other compounds in the JWH series, named after the chemist John W. Huffman, who first synthesized many of these compounds.

Pharmacology

JWH-164 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation.

Legal Status

Due to its potential for abuse and lack of medical use, JWH-164, like many synthetic cannabinoids, is classified as a controlled substance in many jurisdictions. The legal status can vary significantly between countries and regions.

Synthesis

The synthesis of JWH-164 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful handling due to the potential hazards associated with the chemicals involved.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• John W. Huffman