JWH-164

JWH-164 is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a binding affinity of 9.0 nM at CB1 and 2.94 nM at CB2. JWH-164 was first synthesized by organic chemist John W. Huffman.

Chemistry

JWH-164 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is named after its creator, John W. Huffman, an organic chemist who first synthesized these compounds for research purposes.

Pharmacology

JWH-164 acts as a full agonist at the CB1 receptor and the CB2 receptor. The CB1 receptor is primarily located in the brain, and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system. The binding affinity of JWH-164 is 9.0 nM at CB1 and 2.94 nM at CB2.

Effects

The effects of JWH-164 are similar to those of other synthetic cannabinoids and include euphoria, relaxation, and perceptual alterations. However, the exact effects can vary greatly depending on the individual and the dosage used.

Legal Status

The legal status of JWH-164 varies by country and region. In many places, it is classified as a controlled substance due to its potential for abuse and its psychoactive effects.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman