Bufotenin
A naturally occurring psychedelic compound found in various plants and animals
Bufotenin[edit | edit source]
Bufotenin is a naturally occurring tryptamine derivative, chemically known as 5-Hydroxy-N,N-dimethyltryptamine. It is a psychedelic compound found in various plants and animals, including the seeds of the Anadenanthera peregrina tree, commonly known as Yopo.
Chemical Structure and Properties[edit | edit source]
Bufotenin is structurally similar to other tryptamines such as serotonin, psilocybin, and DMT. It has the chemical formula C12H16N2O and is known for its psychoactive properties. The compound acts as a serotonin receptor agonist, particularly at the 5-HT2A receptor, which is believed to be responsible for its hallucinogenic effects.
Sources[edit | edit source]
Bufotenin is found in several natural sources:
- Plants: The seeds of the Anadenanthera peregrina and Anadenanthera colubrina trees contain significant amounts of bufotenin. These seeds are traditionally used in South American shamanic rituals.
- Animals: Bufotenin is also present in the skin secretions of certain toads, such as the Colorado River toad (Incilius alvarius).
Traditional Use[edit | edit source]
In indigenous cultures of South America, bufotenin-containing seeds are used in the preparation of snuffs, such as Yopo and Vilca, which are inhaled during spiritual ceremonies. These practices are believed to facilitate communication with the spirit world and induce visions.
Pharmacology[edit | edit source]
Bufotenin is rapidly metabolized in the human body, primarily by the enzyme monoamine oxidase. This rapid metabolism limits its oral activity, but it can be active when administered via other routes, such as inhalation or injection. The psychoactive effects of bufotenin are characterized by visual hallucinations, altered perception of time, and changes in mood and cognition.
Legal Status[edit | edit source]
The legal status of bufotenin varies by country. In some jurisdictions, it is classified as a controlled substance due to its psychoactive properties, while in others, it remains unregulated.
Related pages[edit | edit source]
Bufotenin 2D structure
Bufotenin 3D molecular model
Yopo seeds containing bufotenin
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