JWH-196

JWH-196 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent and selective CB2 receptor agonist, with a Ki of 2.1 nM and selectivity of around 200 times for CB2 over CB1.

Chemistry

JWH-196 is part of the JWH series, a group of synthetic cannabinoids named after the initials of their developer, John W. Huffman. The chemical structure of JWH-196 is characterized by a naphthoyl group, a 3-carbon alkyl chain, and an indole core, which is a common feature of the naphthoylindole family of synthetic cannabinoids.

Pharmacology

JWH-196 acts as a potent and selective agonist for the CB2 receptor, a type of cannabinoid receptor in the body that is primarily found in the immune system. The Ki value of JWH-196 is 2.1 nM, indicating a high affinity for the CB2 receptor. It has around 200 times selectivity for CB2 over the CB1 receptor, which is primarily found in the brain.

Effects

The effects of JWH-196 are not well-studied in humans. However, due to its high selectivity for the CB2 receptor, it is unlikely to produce the psychoactive effects typically associated with cannabinoids that activate the CB1 receptor. Instead, it may have potential therapeutic effects related to the immune system, as the CB2 receptor is known to play a role in immune function.

Legal Status

The legal status of JWH-196 varies by country and region. In many places, it is considered a controlled substance due to its structural similarity to other synthetic cannabinoids, which are often subject to legal restrictions.

See Also

• JWH-018
• JWH-073
• Synthetic cannabinoids
• Cannabinoid receptor