2,5-Dimethoxy-4-fluoroamphetamine

2,5-Dimethoxy-4-fluoroamphetamine (DOF) is a psychedelic drug and a member of the phenethylamine and amphetamine chemical classes. It is known for its psychedelic effects, which include altered thinking processes, closed and open eye visuals, synesthesia, an altered sense of time, and spiritual experiences.

History

DOF was first synthesized by Alexander Shulgin in 1976. In his book PiHKAL, Shulgin lists the dosage range as 1–3 mg. The duration of action was stated to be 14–20 hours.

Pharmacology

Like other psychedelics, DOF is thought to act primarily as a 5-HT2A receptor agonist. The psychedelic effects are believed to come from DOF's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects

The effects of DOF can vary greatly, depending on the dose and individual's physiology. At lower doses, the effects may be mild and almost indistinguishable from other psychedelics. At higher doses, the effects can be overwhelming and can lead to a state of ego death or complete loss of sense of self.

Legal Status

The legal status of DOF varies from country to country. In the United States, it is not specifically listed as a controlled substance, but it may be considered an analog of other illegal amphetamines under the Federal Analogue Act.

See Also

• 2,5-Dimethoxy-4-chloroamphetamine (DOC)
• 2,5-Dimethoxy-4-bromoamphetamine (DOB)
• 2,5-Dimethoxy-4-iodoamphetamine (DOI)

References

• Shulgin, Alexander; Shulgin, Ann (1991). PiHKAL: A Chemical Love Story. Transform Press. ISBN 0-9630096-0-5.

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