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2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine. Unlike many other substituted amphetamines, however, DOI is often used in scientific research for its psychedelic properties.

Chemistry[edit | edit source]

DOI is a member of the 2C family of psychedelic phenethylamines. It is chemically related to 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2,5-dimethoxy-4-chloroamphetamine (DOC). The full chemical name of DOI is 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane.

Pharmacology[edit | edit source]

DOI acts as a potent and selective 5-HT2A receptor agonist, which is thought to be the primary target responsible for the psychedelic effects of this compound. DOI has been used in animal studies and in vitro to study the function of the 5-HT2A receptor.

Effects[edit | edit source]

The effects of DOI are similar to other psychedelic amphetamines. These effects include open and closed eye visuals, euphoria, time distortion, enhanced introspection, and ego loss. DOI is also known for its strong stimulant effects, due to its action on the norepinephrine and dopamine systems.

Legality[edit | edit source]

DOI is a Schedule I controlled substance in the United States, meaning it is illegal to manufacture, buy, possess, or distribute without a license from the Drug Enforcement Administration (DEA).

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD