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2,5-Dimethoxy-4-bromoamphetamine (also known as DOB) is a psychedelic drug of the amphetamine class. It is known for its potent psychoactive effects and has been used in various scientific research as well as in recreational settings.

Chemistry[edit | edit source]

2,5-Dimethoxy-4-bromoamphetamine is a compound of the phenethylamine class. It consists of an amphetamine backbone where the phenyl ring is substituted at R4 with a bromine atom and at R2 and R5 with methoxy (OCH3) groups.

Pharmacology[edit | edit source]

The pharmacological action of DOB is primarily due to its activity as a serotonin receptor agonist. It has a high affinity for the 5-HT2A and 5-HT2B receptors, which are thought to be the primary targets for its psychedelic effects.

Effects[edit | edit source]

The effects of DOB are often described as similar to those of other psychedelic amphetamines, such as LSD and mescaline. These can include visual hallucinations, enhanced perception, euphoria, and increased introspection. However, DOB is also known for its long duration of action, which can last up to 24 hours or more.

History[edit | edit source]

DOB was first synthesized in 1967 by Alexander Shulgin, a renowned chemist and psychopharmacologist. It was later described in his book PiHKAL (Phenethylamines I Have Known And Loved), where he detailed its synthesis, dosage, duration, and effects.

Legal Status[edit | edit source]

In many countries, including the United States, DOB is classified as a Schedule I drug under the Controlled Substances Act. This means it is illegal to manufacture, distribute, or possess without a license.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD