JWH-120
Overview[edit | edit source]
JWH-120 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Chemical Structure[edit | edit source]
JWH-120 is characterized by its naphthoylindole structure, which includes a naphthalene ring linked to an indole moiety. This structure is crucial for its binding affinity to cannabinoid receptors, particularly CB1 and CB2 receptors.
Pharmacology[edit | edit source]
JWH-120 functions as a full agonist at both CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the immune system and inflammation, as CB2 receptors are primarily located in peripheral tissues and immune cells.
Mechanism of Action[edit | edit source]
Upon binding to cannabinoid receptors, JWH-120 activates the G-protein coupled receptor pathways, leading to the inhibition of adenylate cyclase and a decrease in cyclic AMP levels. This results in various downstream effects, including modulation of neurotransmitter release and immune response.
Potential Applications[edit | edit source]
Research into JWH-120 and similar compounds is ongoing, with potential applications in the treatment of pain, inflammation, and neurological disorders. However, due to its synthetic nature and potential for abuse, it is also a subject of regulatory scrutiny.
Legal Status[edit | edit source]
The legal status of JWH-120 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. Researchers must comply with local regulations when studying this compound.
Safety and Toxicity[edit | edit source]
The safety profile of JWH-120 is not well-established, and its use outside of controlled research settings is not recommended. Potential side effects may include tachycardia, anxiety, and hallucinations, similar to other synthetic cannabinoids.
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Contributors: Prab R. Tumpati, MD
