Metazocine

Metazocine

Metazocine is a benzomorphan derivative and is a mixed agonist–antagonist at opioid receptors. It is a potent analgesic drug that was discovered in the 1960s.

History

Metazocine was first synthesized in the 1960s by medicinal chemists at Sterling Drug. It was part of a series of compounds related to the opioid analgesic morphine.

Pharmacology

Metazocine is a mixed agonist–antagonist at opioid receptors, meaning it can both activate and block these receptors. It has been found to have analgesic (pain-relieving) effects similar to those of morphine. However, unlike morphine, metazocine does not produce the same degree of respiratory depression, which is a common side effect of many opioids.

Medical uses

Metazocine is used for the relief of moderate to severe pain. It can also be used as a preoperative medication to alleviate anxiety and provide analgesia. In some cases, it is used for its sedative effects.

Side effects

Like other opioids, metazocine can cause a range of side effects. These can include drowsiness, dizziness, nausea, and constipation. In some cases, it can also cause respiratory depression, although this is less common than with other opioids.

Legal status

In the United States, metazocine is a Schedule II controlled substance, which means it has a high potential for abuse and is available only by prescription.

See also

• Opioid
• Benzomorphan
• Analgesic
• Agonist–antagonist