JWH-251
JWH-251 is a synthetic cannabinoid from the naphthoylindole family, which acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is one of the most selective CB2 ligands discovered, with a selectivity of over 120 times for CB2 over CB1. This makes it useful for scientific research into the function of the CB2 receptor, as well as the design of CB2 based medicines.
Chemistry[edit | edit source]
JWH-251 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is named after the initials of its discoverer, John W. Huffman, a chemist at Clemson University.
Pharmacology[edit | edit source]
JWH-251 acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is one of the most selective CB2 ligands discovered, with a selectivity of over 120 times for CB2 over CB1. This makes it useful for scientific research into the function of the CB2 receptor, as well as the design of CB2 based medicines.
Legal Status[edit | edit source]
In the United States, JWH-251 is a Schedule I controlled substance. It is also illegal in several other countries, including the United Kingdom and New Zealand.
See Also[edit | edit source]
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