JWH-048

JWH-048 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent cannabinoid receptor agonist. It was first identified by chemist John W. Huffman at Clemson University.

Chemistry

JWH-048 is part of the JWH series of synthetic cannabinoids, named after the initials of their creator, John W. Huffman. It is a naphthoylindole, meaning it is composed of a naphthoyl group attached to an indole core. The specific structure of JWH-048 is characterized by a naphthoyl group attached at the 3-position of the indole, and a pentyl chain attached at the 1-position.

Pharmacology

JWH-048 acts as a potent agonist at the CB1 and CB2 cannabinoid receptors, with a slight preference for the CB2 receptor. The CB1 receptor is primarily located in the brain, and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system, and is involved in immune response and inflammation.

Effects

The effects of JWH-048 are similar to those of other synthetic cannabinoids and include psychoactive effects such as euphoria, altered perception, and increased appetite. However, due to its potency and the lack of knowledge about its safety profile, it can also cause adverse effects such as anxiety, paranoia, and in some cases, severe psychotic reactions.

Legal Status

The legal status of JWH-048 varies by country. In many countries, including the United States, it is classified as a Schedule I controlled substance, making it illegal to manufacture, distribute, or possess.

See Also

• JWH series
• Synthetic cannabinoids
• Cannabinoid receptor

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