JWH-048
Overview[edit | edit source]
JWH-048 is a synthetic cannabinoid that acts as an agonist at the cannabinoid receptors. It is part of the JWH series of compounds, which were developed by Dr. John W. Huffman in the 1990s for research purposes. These compounds are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the active component in cannabis.
Chemical Structure[edit | edit source]
JWH-048 is classified as a naphthoylindole, a type of synthetic cannabinoid. Its chemical structure includes a naphthalene group attached to an indole core, which is a common feature among many synthetic cannabinoids. This structure allows JWH-048 to bind to the CB1 and CB2 receptors in the brain, producing psychoactive effects.
Pharmacology[edit | edit source]
JWH-048 acts as a full agonist at both the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The activation of these receptors by JWH-048 can lead to effects similar to those of THC, including euphoria, altered perception, and relaxation.
Legal Status[edit | edit source]
The legal status of JWH-048 varies by country. In many places, it is classified as a controlled substance due to its potential for abuse and lack of medical use. The United States and several European Union countries have banned the sale and possession of JWH-048 and other synthetic cannabinoids.
Health Effects[edit | edit source]
The use of JWH-048 can lead to a range of health effects, both acute and chronic. Acute effects may include tachycardia, anxiety, paranoia, and hallucinations. Chronic use can lead to dependence and withdrawal symptoms. The long-term health effects of synthetic cannabinoids like JWH-048 are not well understood, but they may pose significant risks to users.
Related Compounds[edit | edit source]
JWH-048 is part of a larger group of synthetic cannabinoids, including JWH-018, JWH-073, and JWH-200. These compounds share similar structures and pharmacological profiles, but they can vary in potency and duration of effects.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
