JWH-149
JWH-149 is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a binding affinity of 9.0 nM at CB1 and 2.94 nM at CB2. JWH-149 was first synthesized by organic chemist John W. Huffman.
Chemistry[edit | edit source]
JWH-149 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is named after the initials of its creator, John W. Huffman, followed by a number representing the order in which it was synthesized.
Pharmacology[edit | edit source]
JWH-149 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. It has a binding affinity of 9.0 nM at CB1 and 2.94 nM at CB2. The effects of JWH-149 are similar to those of tetrahydrocannabinol (THC), the main active ingredient in cannabis.
Legal Status[edit | edit source]
The legal status of JWH-149 varies by country. In the United States, it is a Schedule I controlled substance. In other countries, it may be legal or illegal depending on the specific laws regarding synthetic cannabinoids.
See Also[edit | edit source]
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