JWH-149

JWH-149 is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a binding affinity of 9.0 nM at CB₁ and 2.94 nM at CB₂. JWH-149 was first synthesized by organic chemist John W. Huffman.

Chemistry

JWH-149 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is named after the initials of its creator, John W. Huffman, followed by a number representing the order in which it was synthesized.

Pharmacology

JWH-149 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors. It has a binding affinity of 9.0 nM at CB₁ and 2.94 nM at CB₂. The effects of JWH-149 are similar to those of tetrahydrocannabinol (THC), the main active ingredient in cannabis.

Legal Status

The legal status of JWH-149 varies by country. In the United States, it is a Schedule I controlled substance. In other countries, it may be legal or illegal depending on the specific laws regarding synthetic cannabinoids.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman

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