JWH-398

JWH-398 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent cannabinoid receptor agonist. It has binding affinity for both the CB1 and CB2 receptors, with a slight preference for the CB2 receptor. JWH-398 is one of the numerous synthetic cannabinoids used in designer drugs such as Spice and K2.

Chemistry

JWH-398 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is named after the initials of its developer, John W. Huffman, a chemist at Clemson University who first synthesized these compounds in the 1990s.

Pharmacology

JWH-398 acts as a full agonist at the CB1 and CB2 cannabinoid receptors. It has a slight preference for the CB2 receptor, which is primarily found in the immune system. The effects of JWH-398 are similar to those of tetrahydrocannabinol (THC), the main active ingredient in cannabis, but it is much more potent.

Effects

The effects of JWH-398 can include relaxation, euphoria, altered perception, and in some cases, hallucinations. However, it can also cause adverse effects such as anxiety, paranoia, and tachycardia. Due to its potency and the lack of knowledge about its long-term effects, JWH-398 and other synthetic cannabinoids are considered to be dangerous substances.

Legal Status

The legal status of JWH-398 varies by country. In many countries, including the United States, it is classified as a Schedule I drug, making it illegal to manufacture, distribute, or possess.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• JWH-073