JWH-167

JWH-167 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent and selective CB2 receptor agonist. It was discovered and named after John W. Huffman, a researcher at Clemson University.

Chemistry

JWH-167 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. The compound is a potent and selective agonist for the CB2 receptor, with a binding affinity of 2.94 nM, and 100 times selectivity over the CB1 receptor.

Pharmacology

The CB2 receptor is primarily found in the immune system, and is less prevalent in the brain than the CB1 receptor. Activation of the CB2 receptor leads to anti-inflammatory and potentially anti-cancer effects. However, the exact mechanisms of action of JWH-167 are not fully understood, and further research is needed to determine its potential therapeutic uses and side effects.

Legal Status

As a synthetic cannabinoid, JWH-167 is illegal in many countries. It is often included in the same legal category as cannabis and other synthetic cannabinoids. However, the legal status can vary by country and even by state or region within a country.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman

References

JWH-167 Resources
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