JWH-148

JWH-148.png

JWH-148 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist for the cannabinoid receptors, specifically the CB1 receptor and CB2 receptor.

Chemical Structure and Properties

JWH-148 is chemically classified as a naphthoylindole. Its full chemical name is 1-Pentyl-3-(1-naphthoyl)indole. The compound has a molecular formula of C24H23NO and a molecular weight of 341.45 g/mol.

Pharmacology

JWH-148 functions as a potent agonist for the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. These receptors are involved in various physiological processes including pain sensation, mood, and memory. The binding affinity of JWH-148 to these receptors is high, making it a significant compound for research in cannabinoid receptor activity.

Legal Status

The legal status of JWH-148 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. It is often included in legislation aimed at regulating synthetic cannabinoids.

Research and Applications

JWH-148 has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It has also been utilized in the development of new therapeutic agents targeting these receptors.

Safety and Toxicity

The safety profile and toxicity of JWH-148 are not well-documented. As with other synthetic cannabinoids, there may be risks associated with its use, including potential for abuse and adverse health effects.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• JWH-073