JWH-148

JWH-148 is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, but with moderate selectivity for CB₂. It was discovered by and named after Dr. John W. Huffman.

Chemistry

JWH-148 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids including JWH-018, JWH-073, and JWH-200.

Pharmacology

JWH-148 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a moderate selectivity for the CB₂ receptor. The CB₁ receptor is primarily located in the brain, and its activation results in the psychoactive effects of cannabis. The CB₂ receptor is primarily found in the immune system.

Legality

In many jurisdictions, JWH-148 is not specifically listed as illegal, but its sale may be controlled under analog laws which cover any chemical similar in structure and/or pharmacological effect to a scheduled substance.

See also

• Cannabinoid receptor
• Synthetic cannabinoids
• JWH-018
• JWH-073
• JWH-200

JWH-148 Resources
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