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1V-LSD (also known as 1-valeroyl-lysergic acid diethylamide) is a semisynthetic psychedelic drug of the lysergamide class. It is an analog of LSD and is named for the valeric acid attached to the nitrogen molecule of LSD's indole.

History[edit | edit source]

1V-LSD was first synthesized by the Swiss chemist Albert Hofmann in the 1960s, but it did not gain popularity until the 2010s. It is part of a larger group of LSD analogs, including AL-LAD, ETH-LAD, and 1P-LSD.

Pharmacology[edit | edit source]

Like other lysergamides, 1V-LSD likely acts as a 5-HT2A receptor agonist. However, the exact mechanism of action is not fully understood. It is thought that the drug's psychedelic effects come from its efficacy at the 5-HT2A receptors distributed throughout the brain.

Effects[edit | edit source]

The effects of 1V-LSD are similar to those of LSD, but with a slightly longer duration. Users report visual hallucinations, altered thinking processes, closed and open eye visuals, synesthesia, an altered sense of time, and spiritual experiences.

Legal Status[edit | edit source]

The legal status of 1V-LSD varies by country. In many countries, it is a controlled substance, similar to other LSD analogs. However, in some countries, it is legal to possess and use.

Safety[edit | edit source]

As with all psychedelics, 1V-LSD can cause adverse psychological reactions such as anxiety, paranoia, and delusions. There are no known physical health risks, but the drug's effects on the brain are not fully understood.

See Also[edit | edit source]

Psychedelic art.jpg

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Contributors: Prab R. Tumpati, MD