JWH-198
Overview[edit | edit source]
JWH-198 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component in cannabis.
Chemical Structure[edit | edit source]
JWH-198 is chemically classified as a naphthoylindole, with the full chemical name being 1-Pentyl-3-(4-methoxynaphthoyl)indole. The structure consists of a naphthalene ring system attached to an indole core, with a methoxy group at the 4-position of the naphthalene ring and a pentyl chain at the 1-position of the indole.
Pharmacology[edit | edit source]
JWH-198 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, and pain sensation.
CB1 Receptor[edit | edit source]
The CB1 receptor is primarily found in the central nervous system, and its activation by JWH-198 can lead to psychoactive effects similar to those produced by THC.
CB2 Receptor[edit | edit source]
The CB2 receptor is mainly located in the immune system and peripheral tissues. Activation of this receptor by JWH-198 is associated with anti-inflammatory effects and modulation of immune responses.
Legal Status[edit | edit source]
The legal status of JWH-198 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Potential Effects and Risks[edit | edit source]
The use of JWH-198, like other synthetic cannabinoids, can lead to a range of effects, including euphoria, altered perception, and relaxation. However, it can also cause adverse effects such as anxiety, paranoia, and in some cases, severe health complications.
Related Compounds[edit | edit source]
JWH-198 is part of a larger group of synthetic cannabinoids, including JWH-018, JWH-073, and JWH-250, which share similar structures and pharmacological profiles.
Related Pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
