Pridopidine

Pridopidine is a drug that is currently under investigation for its potential use in the treatment of Huntington's disease. It is a dopamine stabilizer that was originally developed by NeuroSearch, and is now being developed by Prilenia Therapeutics.

Mechanism of action[edit | edit source]

Pridopidine acts as a dopamine D2 receptor antagonist, and has a high affinity for sigma-1 receptors. The drug's mechanism of action is not fully understood, but it is believed to improve motor function and reduce motor symptoms in patients with Huntington's disease.

Clinical trials[edit | edit source]

Several clinical trials have been conducted to evaluate the safety and efficacy of pridopidine in patients with Huntington's disease. The results of these trials have been mixed, with some showing a significant improvement in motor function, while others have shown no significant difference between pridopidine and a placebo.

Side effects[edit | edit source]

The most common side effects of pridopidine include nausea, fatigue, and insomnia. In rare cases, pridopidine can cause serious side effects such as akathisia and dyskinesia.

Future developments[edit | edit source]

Research is ongoing to determine the long-term effects of pridopidine and its potential use in other neurodegenerative diseases. Prilenia Therapeutics is currently conducting a Phase III clinical trial to further evaluate the drug's efficacy and safety.

See also[edit | edit source]

Pridopidine Resources
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