Zuclopenthixol decanoate
Zuclopenthixol decanoate is a typical antipsychotic drug used in the treatment of schizophrenia and other psychotic disorders. It is a long-acting injectable form of zuclopenthixol, a thioxanthene derivative.
Pharmacology[edit | edit source]
Zuclopenthixol decanoate is a dopamine antagonist, specifically of the D1 receptor and D2 receptor. It also has affinity for the serotonin receptors, specifically 5-HT2A and 5-HT2C. The drug's antipsychotic activity is thought to be related to its ability to block dopamine receptors.
Clinical use[edit | edit source]
Zuclopenthixol decanoate is used in the management of schizophrenia and other psychotic disorders where patients have difficulty in complying with oral medication. It is administered by deep intramuscular injection. The drug has a long duration of action, making it suitable for monthly administration.
Side effects[edit | edit source]
Common side effects of zuclopenthixol decanoate include extrapyramidal symptoms, dystonia, akathisia, parkinsonism, and tardive dyskinesia. Other side effects can include drowsiness, blurred vision, dry mouth, and constipation.
See also[edit | edit source]
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