Tizanidine

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Information about Tizanidine[edit source]

Tizanidine is a commonly used muscle relaxant that has been linked to rare instances of acute liver injury, a few of which have been fatal.

Mechanism of action of Tizanidine[edit source]

Tizanidine (tye zan' i deen) is an imidazoline derivative and is a centrally acting muscle relaxant used for therapy of acute muscle spasms and chronic spasticity.  The mechanism by which tizanidine causes skeletal muscle relaxation is not well known; it appears to act at the level of spinal cord pain reflexes, most likely through activity as a central alpha-adrenergic agonist which results in an decrease in activity of motor neurons.  Tizanidine was approved for use in the United States in 1996 and currently several million prescriptions are filled yearly. 

Clinical use of Tizanidine[edit source]

The current indications are limited to short-term management of spasticity. 

Dosage and administration for Tizanidine[edit source]

Tizanidine is available in several generic forms as well as under the brand name of Zanaflex in tablets and capsules of 2, 4 or 6 mg.  The recommended dose in adults is 2 to 6 mg orally three to four times daily. 

Side effects of Tizanidine[edit source]

Common side effects include tiredness, drowsiness, dizziness, muscular weakness, dry mouth and occasionally hypotension.


Muscle relaxants

Tizanidine Resources

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Contributors: Prab R. Tumpati, MD, Spt