Naphazoline
What is Naphazoline?[edit | edit source]
- Naphazoline (Privine and Sudafed) is, an ocular vasoconstrictor, an imidazoline derivative sympathomimetic amine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye.
What are the uses of this medicine?[edit | edit source]
Naphazoline (Privine and Sudafed) used temporary relief of nasal congestion:
- due to a cold
- due to hay fever or other upper respiratory allergies
- shrinks swollen membranes so you can breathe more freely
As Eye drops (brand names Clear Eyes, and Cleari) used for temporary relief of redness and discomfort due to:
- minor eye irritations
- exposure to wind or sun
- dryness of the eye
- prevents further irritation
How does this medicine work?[edit | edit source]
- Naphazoline constricts the vascular system of the conjunctiva.
- It is presumed that this effect is due to direct stimulation of the drug upon the alpha-adrenergic receptors in the arterioles of the conjunctiva, resulting in decreased conjunctival congestion.
- Naphazoline belongs to the imidazoline class of sympathomimetics.
Who Should Not Use this medicine ?[edit | edit source]
This medicine cannot be used in patients who:
- are taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl
- Hypersensitivity to naphazoline
- Severe cardiovascular disease including cardiac arrhythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis
What drug interactions can this medicine cause?[edit | edit source]
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Be sure to mention any of the following:
- MAO inhibitors
- anaesthetics (e.g. cyclopropane or halothane)
- phenylephrine
Is this medicine FDA approved?[edit | edit source]
- It was patented in 1934 and came into medical use in 1942.
How should this medicine be used?[edit | edit source]
Recommended dosage: adults and children 12 years of age and over:
- 1 or 2 sprays in each nostril not more often than every 6 hours.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form:
- As nasal spray Naphazoline HCl, USP 0.05%
- Naphazoline Hydrochloride Ophthalmic Solution
This medicine is available in fallowing brand namesː
- Privine and Sudafed; Clear Eyes, and Cleari
What side effects can this medication cause?[edit | edit source]
- The most common side effects of this medicine include:
In Nasal administration:
In Ophthalmic use:
- Stinging
- Discomfort
- Irritation
- Increased red eyes
- Blurred vision
- Mydriasis
- Punctate keratitis
- Lacrimation (tears)
- Increased intraocular pressure
What special precautions should I follow?[edit | edit source]
- Do not exceed recommended dosage
- Temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge may occur
- Do not use for more than 3 days. Frequent or prolonged use may cause nasal congestion to come back or get worse.
- Use only as directed.
- Stop use and ask a doctor if symptoms persist.
- The use of this container by more than one person may spread infection.
Tell your a doctor before use if you have:
- heart disease
- thyroid disease
- high blood pressure
- diabetes
- trouble urinating due to an enlarged prostate gland
- Patients under therapy with MAO inhibitors may experience a severe hypertensive crisis if given a sympathomimetic drug. Use in children, especially infants, may result in CNS depression leading to coma and marked reduction in body temperature.
What to do in case of emergency/overdose?[edit | edit source]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
- Pregnancy Category C.
- It is also not known whether naphazoline can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Naphazoline should be given to a pregnant woman only if clearly needed.
Can this medicine be used in children?[edit | edit source]
- Safety and effectiveness in pediatric patients have not been established.
What are the active and inactive ingredients in this medicine?[edit | edit source]
Active ingredients:
- naphazoline hydrochloride
Inactive Ingredients:
- edetate disodium
- water
- sodium chloride
- SODIUM CARBONATE
- BENZALKONIUM CHLORIDE
- HYDROCHLORIC ACID
- BORIC ACID
Who manufactures and distributes this medicine?[edit | edit source]
Naphazoline Hydrochloride Ophthalmic Solution: Manufactured by:
- Akorn Inc.
- Lake Forest, IL
Naphazoline hydrochloride spray: Distributed by:
- INSIGHT Pharmaceuticals Corp.
- Langhorne, PA
What should I know about storage and disposal of this medication?[edit | edit source]
- store at room temperature 20°–25°C (68°–77°F).
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