Mast cell stabilizer

Mast cell stabilizers are a type of medication used primarily to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One such drug is cromolyn sodium.

Mechanism of action

Mast cell stabilizers work by preventing the mast cell from releasing inflammatory mediators. They do this by stabilizing the mast cell's membrane, making it more difficult for stimuli to cause degranulation. This means that even if the mast cell is exposed to an allergen, it is less likely to release histamine.

Uses

Mast cell stabilizers are used in the treatment of a variety of conditions, including asthma, allergic rhinitis, and certain skin conditions such as urticaria and atopic dermatitis. They are also used in the management of food allergies and exercise-induced asthma.

Side effects

Like all medications, mast cell stabilizers can have side effects. These can include cough, throat irritation, and gastrointestinal disturbances. However, these side effects are generally mild and go away on their own.

Examples

There are several different mast cell stabilizers available. These include:

• Cromolyn sodium
• Nedocromil
• Lodoxamide
• Pemirolast

See also

• Antihistamine
• Leukotriene antagonist
• Immunotherapy