Butofilolol

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Butofilolol is a beta-adrenergic antagonist (beta-blocker) used in the treatment of hypertension and other cardiovascular conditions. It is a non-selective beta-blocker, meaning it blocks both beta-1 and beta-2 adrenergic receptors.

Pharmacology

Butofilolol works by inhibiting the action of epinephrine and norepinephrine on beta-adrenergic receptors, which are part of the sympathetic nervous system. This leads to a decrease in heart rate, cardiac output, and blood pressure. By reducing the workload on the heart, butofilolol helps to manage conditions such as angina pectoris and myocardial infarction.

Indications

Butofilolol is primarily indicated for:

• Hypertension
• Angina pectoris
• Arrhythmia
• Myocardial infarction

Side Effects

Common side effects of butofilolol include:

• Bradycardia
• Hypotension
• Fatigue
• Dizziness
• Cold extremities

Less common but more serious side effects may include:

• Bronchospasm
• Heart failure
• Depression

Contraindications

Butofilolol should not be used in patients with:

• Asthma or other severe COPD
• Severe bradycardia
• Cardiogenic shock
• Second or third-degree heart block without a pacemaker

Mechanism of Action

Butofilolol blocks the beta-adrenergic receptors in the heart and blood vessels. This action reduces the effects of sympathetic nervous system stimulation, leading to a decrease in heart rate and blood pressure. The reduction in cardiac output and peripheral resistance helps to lower blood pressure and reduce the oxygen demand of the heart.

Dosage and Administration

The dosage of butofilolol varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally, and the dosage may be adjusted based on the patient's blood pressure and heart rate.

See Also

• Beta blocker
• Hypertension
• Cardiovascular disease
• Adrenergic receptor