PRE-084

A sigma receptor agonist

PRE-084
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CAS Number	140376-53-4
PubChem	3086015
DrugBank
ChemSpider	2340985
KEGG

PRE-084 is a synthetic compound that acts as a selective agonist for the sigma-1 receptor. It is primarily used in scientific research to study the role of sigma receptors in the central nervous system and their potential therapeutic applications.

Chemical Structure and Properties

PRE-084 is chemically known as 2-(4-Methoxyphenyl)-1-[2-(N-pyrrolidinyl)ethyl]-4-methyl-1H-pyrrole. It has a molecular formula of C₁₆H₂₃N₂O and a molecular weight of 259.37 g/mol. The compound features a pyrrole ring substituted with a methoxyphenyl group and a pyrrolidinyl ethyl chain.

Mechanism of Action

PRE-084 functions as an agonist at the sigma-1 receptor, a chaperone protein located in the endoplasmic reticulum of cells. The activation of sigma-1 receptors by PRE-084 modulates various cellular processes, including calcium signaling, neuroprotection, and neuroplasticity. These receptors are implicated in the regulation of ion channels, neurotransmitter release, and apoptosis.

Pharmacological Effects

Research indicates that PRE-084 exhibits neuroprotective effects, potentially offering therapeutic benefits in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It has been shown to enhance cognitive function and memory in animal models. Additionally, PRE-084 may have antidepressant and anxiolytic properties, making it a compound of interest in the study of mental health disorders.

Research Applications

PRE-084 is widely used in preclinical studies to explore the physiological and pathological roles of sigma-1 receptors. It serves as a tool to investigate the potential of sigma-1 receptor modulation in treating various conditions, including neuropathic pain, stroke, and schizophrenia.

Safety and Toxicity

While PRE-084 is primarily used in research settings, its safety profile in humans is not well-established. Studies in animal models suggest that it is generally well-tolerated at research doses, but further investigation is needed to determine its safety and efficacy in humans.

Related Pages

• Sigma-1 receptor
• Neuroprotection
• Neurodegenerative diseases
• Cognitive function