PRE-084
PRE-084 is a sigma receptor agonist, selective for the σ1 subtype. It has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects.[1][2][3][4][5] PRE-084 increases the expression of GDNF.[6]
References[edit | edit source]
- ↑ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A, PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice, Pharmacology, Biochemistry, and Behavior, Vol. 49(Issue: 4), pp. 859–69, DOI: 10.1016/0091-3057(94)90235-6, PMID: 7886099,
- ↑ Maurice T, Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats, European Journal of Pharmacology, Vol. 431(Issue: 2), pp. 223–7, DOI: 10.1016/S0014-2999(01)01436-4, PMID: 11728429,
- ↑ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL, Antitussive activity of sigma-1 receptor agonists in the guinea-pig, British Journal of Pharmacology, Vol. 141(Issue: 2), pp. 233–40, DOI: 10.1038/sj.bjp.0705605, PMID: 14691051, PMC: 1574192,
- ↑ Skuza G, Rogóz Z, Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice, Pharmacological Reports : PR, 2009, Vol. 61(Issue: 6), pp. 1179–83, PMID: 20081254,
- ↑ Hiranita T, Soto PL, Tanda G, Katz JL, Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine, The Journal of Pharmacology and Experimental Therapeutics, Vol. 332(Issue: 2), pp. 515–24, DOI: 10.1124/jpet.109.159236, PMID: 19892920, PMC: 2812106,
- ↑ Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X, Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury, J. Neurotrauma, Vol. 28(Issue: 5), pp. 831–40, DOI: 10.1089/neu.2010.1674, PMID: 21332255,
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