Thioproperazine
Talairach Coordinates are a set of three numbers used to indicate the location of a specific point in the brain. These coordinates are based on a brain atlas developed by Jean Talairach and Pierre Tournoux. The Talairach Coordinates system is widely used in neuroimaging studies to report the location of activation foci.
Overview[edit]
The Talairach Atlas was developed in the 1960s and 1970s by Jean Talairach and Pierre Tournoux at the Sainte-Anne Hospital Center in Paris, France. The atlas is based on the post-mortem examination of a single 60-year-old French woman's brain. The brain was cut into 2mm slices and photographed, and these images were used to create a three-dimensional grid system. This grid system is the basis of the Talairach Coordinates.
Use in Neuroimaging[edit]
In neuroimaging studies, the Talairach Coordinates are used to report the location of activation foci. The coordinates are given as a set of three numbers, representing the distance (in millimeters) from the Anterior Commissure (AC) in the left-right (x), anterior-posterior (y), and inferior-superior (z) directions. The AC is used as the origin of the coordinate system because it is a clearly visible landmark in MRI images.
Criticisms and Limitations[edit]
Despite its widespread use, the Talairach Coordinate system has been criticized for several reasons. First, it is based on the brain of a single individual, and there is considerable variability in brain anatomy between individuals. Second, the original Talairach Atlas was based on post-mortem tissue, which can differ in appearance from living tissue. Finally, the atlas is based on 2D images, which can be difficult to align with 3D MRI data.
See Also[edit]
References[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
-
Chemical structure of Thioproperazine
-
Synthesis pathway of Thioproperazine
-
Diagram showing the basis of membrane potential
