Doxanthrine

From WikiMD.com Medical Encyclopedia

Doxanthrine[edit | edit source]

Chemical structure of Doxanthrine

Doxanthrine is a synthetic compound that acts as a selective agonist for the dopamine receptor D1. It is primarily used in research settings to study the effects of D1 receptor activation in the central nervous system.

Pharmacology[edit | edit source]

Doxanthrine is known for its high affinity and selectivity towards the dopamine receptor D1 subtype. This selectivity makes it a valuable tool in neuropharmacological research, allowing scientists to investigate the specific roles of D1 receptors in various physiological and pathological processes.

Mechanism of Action[edit | edit source]

Doxanthrine binds to the D1 receptor, a G protein-coupled receptor (GPCR), and activates it. This activation leads to the stimulation of adenylate cyclase, increasing the levels of cyclic adenosine monophosphate (cAMP) within the cell. The rise in cAMP levels triggers a cascade of intracellular events that ultimately result in the modulation of neuronal activity.

Applications in Research[edit | edit source]

Doxanthrine is utilized in various research studies to explore the role of D1 receptors in the brain. It has been used to:

Safety and Toxicity[edit | edit source]

As a research chemical, the safety and toxicity profile of Doxanthrine in humans is not well-established. Studies in animal models are typically conducted to assess its pharmacokinetics and potential side effects. Researchers handling Doxanthrine must adhere to appropriate safety protocols to minimize any risks associated with its use.

Related pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD