Tropisetron

Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.

Pharmacology

Tropisetron acts as both a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist. Tropisetron is a well-tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects. These side effects are generally mild and transient.

Chemistry

Tropisetron is a carbazole derivative with antiemetic activity. As a competitive antagonist at the 5-HT3 receptor, tropisetron blocks the action of serotonin, a neurotransmitter that may cause nausea and vomiting.

Clinical use

Tropisetron is used to treat nausea and vomiting caused by chemotherapy or surgery. It is also used experimentally in the treatment of fibromyalgia.

See also

• 5-HT3 antagonist
• Antiemetic
• Chemotherapy
• Fibromyalgia

References

Tropisetron Resources
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