Tropisetron

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Medication used to treat nausea and vomiting

Tropisetron


Trade names Navoban


Chemical nomenclature
IUPAC name (3aS)-2,3,3a,4,5,6-Hexahydro-1H-indole-3-carboxylic acid [1-methyl-1H-indol-3-yl]-methyl ester



Routes Oral, Intravenous







Identifiers
CAS Number 89565-68-4
PubChem 5583
DrugBank DB00757
ChemSpider 5383
UNII 1C83566V6M
KEGG D00372
ChEMBL 1201310
Chemical data


Chemical formula C17H20N2O2


SMILES CC1(C2=CC=CC=C2NC1)C(=O)OCC3=CN(C)C4=CC=CC=C34




Tropisetron is a pharmaceutical drug used primarily as an antiemetic to treat nausea and vomiting caused by chemotherapy and radiotherapy. It is also used to prevent postoperative nausea and vomiting. Tropisetron is a selective 5-HT3 receptor antagonist, which means it works by blocking the action of serotonin at the 5-HT3 receptors.

Medical uses[edit]

Tropisetron is indicated for the prevention and treatment of nausea and vomiting induced by chemotherapy and radiotherapy. It is also used to prevent postoperative nausea and vomiting. The drug is administered either orally or intravenously.

Mechanism of action[edit]

Tropisetron works by selectively blocking the 5-HT3 receptors in the central nervous system and the gastrointestinal tract. By inhibiting the action of serotonin at these receptors, it prevents the activation of the vomiting reflex.

Pharmacokinetics[edit]

Tropisetron is well absorbed after oral administration. It undergoes hepatic metabolism and is excreted primarily via the kidneys. The elimination half-life of tropisetron is approximately 8 hours.

Side effects[edit]

Common side effects of tropisetron include headache, constipation, and dizziness. Rare but serious side effects may include allergic reactions and cardiac arrhythmias.

Contraindications[edit]

Tropisetron is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with hepatic impairment or renal impairment.

See also[edit]

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  • Tropisetron 2D Structure
    Tropisetron 2D Structure
  • Tropisetron 3D Animation
    Tropisetron 3D Animation

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