Cloroqualone

Cloroqualone is a Quinazolinone derivative, which is a type of sedative and hypnotic drug. It is related to other quinazolinone derivatives such as afloqualone and etaqualone.

History

Cloroqualone was developed in the 1950s by a team at William S. Merrell Company. It was marketed as a sleeping pill under the brand name Dormutil.

Pharmacology

Cloroqualone is a GABA_A receptor positive allosteric modulator. This means it enhances the effect of the neurotransmitter GABA on the GABA_A receptor, leading to sedative and hypnotic effects.

Side Effects

Like other sedative-hypnotic drugs, cloroqualone can cause a range of side effects. These can include dizziness, nausea, vomiting, and respiratory depression. In severe cases, it can lead to coma or death.

Legal Status

Cloroqualone is a Schedule III drug under the Convention on Psychotropic Substances. This means it is subject to international control and restrictions.

See Also

• Quinazolinone
• GABA_A receptor
• Convention on Psychotropic Substances

Cloroqualone Resources
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