Gamma-Aminobutyric acid

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Gamma-Aminobutyric acid (also known as GABA) is a naturally occurring amino acid that works as a neurotransmitter in your brain. Neurotransmitters function as chemical messengers. GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system.

Etymology[edit | edit source]

The term "Gamma-Aminobutyric acid" is derived from its chemical structure, which consists of an amino group (NH2) connected to a butyric acid molecule. The "gamma" refers to the third carbon in the butyric acid chain where the amino group is attached.

Function[edit | edit source]

When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. This can help with feelings of anxiety, stress, and fear. It may also help to prevent seizures.

Related Compounds[edit | edit source]

GABA is related to two other amino acids: L-glutamine and L-theanine. L-glutamine is used by the body to create GABA. L-theanine, on the other hand, can increase levels of GABA in the body.

Medical Uses[edit | edit source]

Because of its calming effect, GABA is used as a natural supplement to help reduce stress and anxiety, improve mood, and promote sleep. It's also used in the medical field to help treat conditions like epilepsy and Parkinson's disease.

Side Effects[edit | edit source]

While GABA is generally safe for most people, it can cause some side effects, including a slowed heart rate, stomach upset, and a tingling sensation in the limbs. It's also not recommended for pregnant or breastfeeding women.

See Also[edit | edit source]

Gamma-Aminobutyric acid Resources
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Contributors: Prab R. Tumpati, MD