Paraldehyde

Paraldehyde is a sedative and hypnotic drug that was first synthesized in the 19th century. It is primarily used in the treatment of insomnia and seizure disorders.

History[edit | edit source]

Paraldehyde was first synthesized in 1829 by the German chemist Justus von Liebig. It was initially used as a solvent in the manufacture of rubber and plastics, but its medical uses were soon discovered. In the late 19th and early 20th centuries, it was widely used as a sedative and hypnotic, particularly in the treatment of alcohol withdrawal and delirium tremens.

Medical Uses[edit | edit source]

Today, paraldehyde is primarily used in the treatment of severe insomnia and seizure disorders. It is particularly effective in treating status epilepticus, a life-threatening condition in which seizures occur in rapid succession or last for a prolonged period of time. Paraldehyde is also used in the treatment of tetanus, a bacterial infection that causes severe muscle spasms.

Side Effects[edit | edit source]

Like all drugs, paraldehyde can have side effects. These can include nausea, vomiting, abdominal pain, and diarrhea. In rare cases, it can cause respiratory depression, a serious condition in which breathing becomes dangerously slow or shallow.

Pharmacology[edit | edit source]

Paraldehyde works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits the activity of nerve cells in the brain. This has a calming effect, which can help to induce sleep and reduce the frequency and severity of seizures.

See Also[edit | edit source]

Paraldehyde Resources
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