GBR-12935

GBR-12935 is a piperazine derivative that inhibits the dopamine transporter, preventing the reuptake of dopamine in the brain. It is primarily used in scientific research to study the effects of increased dopamine levels.

Chemistry

GBR-12935 is a phenyltropane based compound. The structure of GBR-12935 is similar to that of cocaine, but it has a different mechanism of action. Unlike cocaine, which is a dopamine reuptake inhibitor, GBR-12935 is a dopamine transporter inhibitor.

Pharmacology

GBR-12935 binds to the dopamine transporter, blocking the reuptake of dopamine into the presynaptic neuron. This leads to an increase in the concentration of dopamine in the synaptic cleft, which can result in increased dopamine receptor activation.

Uses in Research

GBR-12935 is used in research to study the role of dopamine in various physiological and pathological processes. It has been used in studies investigating the role of dopamine in Parkinson's disease, schizophrenia, and drug addiction.

Side Effects

As with any drug that alters dopamine levels, GBR-12935 can have side effects. These can include nausea, vomiting, and anxiety. However, these side effects are generally mild and temporary.

See Also

• Dopamine transporter
• Dopamine reuptake inhibitor
• Phenyltropane

References

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