Vanoxerine
Vanoexerine is a pharmacological compound that was initially developed for the treatment of cardiac arrhythmia. However, it has been repurposed and is currently being studied for its potential use in the treatment of drug addiction and Parkinson's disease.
History[edit | edit source]
Vanoexerine was first synthesized in the 1970s by the pharmaceutical company G.D. Searle & Company. It was initially developed as an antiarrhythmic drug, but its development was discontinued due to its potential to cause torsades de pointes, a type of life-threatening ventricular tachycardia.
Pharmacology[edit | edit source]
Vanoexerine is a potent and selective inhibitor of the dopamine transporter (DAT), which is responsible for the reuptake of dopamine in the brain. By blocking the reuptake of dopamine, vanoexerine increases the amount of dopamine available in the brain. This mechanism of action is similar to that of other drugs used in the treatment of Parkinson's disease and drug addiction.
Clinical Trials[edit | edit source]
In recent years, vanoexerine has been studied for its potential use in the treatment of drug addiction. In preclinical studies, it has been shown to reduce self-administration of cocaine and methamphetamine in animal models. Clinical trials are currently underway to evaluate the safety and efficacy of vanoexerine in humans with drug addiction.
Vanoexerine is also being studied for its potential use in the treatment of Parkinson's disease. In preclinical studies, it has been shown to have neuroprotective effects and to improve motor function in animal models of Parkinson's disease. Clinical trials are currently underway to evaluate the safety and efficacy of vanoexerine in humans with Parkinson's disease.
See Also[edit | edit source]
References[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
