Muscle relaxants
muscle relaxants is a group of drugs used to relieve muscle spasm and to treat conditions such as arthritis, back pain, and nervous system disorders such as stroke and cerebral palsy
Information about Muscle relaxants[edit source]
Muscle relaxants are used to treat two different conditions: (1) spasticity from upper motor neuron syndromes as occurs in multiple sclerosis and (2) muscular pain or spasms from peripheral musculoskeletal diseases or injury such as low back pain. The muscle relaxants in current use have variable mechanisms of action, efficacy and adverse effects. This class of medications is well tolerated, with the most common side effects being drowsiness and nausea.
Liver toxicity of Muscle relaxants[edit source]
Muscle relaxants are said to be associated with asymptomatic elevations in serum aminotransferase levels in up to 5% of subjects, but the rate of such elevations may be the same in control, untreated subjects, and significant elevations (greater than 3 times the upper limit of normal) are rare. The majority of the published clinical trials evaluating the safety of muscle relaxants do not mention hepatotoxicity or aminotransferase elevations. Rare cases of drug induced jaundice have occurred with some, but not all of the muscle relaxants. Agents that have been fairly clearly linked to clinically apparent acute liver injury include chlorzoxazone, dantrolene, and tizanidine. Cases of acute liver failure and death have been reported after chlorzoxazone and dantrolene therapy. Very rare instances of clinically signficiant liver injury have been reported with quinine and baclofen. On the other hand, there is little evidence to suggest that carisoprodol, cyclobenzaprine, metaxalone, methocarbamol or orphenadrine are associated with significant liver injury and, if it occurs, hepatotoxicity from these agents must be exceedingly rare.
- Baclofen
- Carisoprodol
- Chlorzoxazone
- Cyclobenzaprine
- Dantrolene
- Metaxalone
- Methocarbamol
- Orphenadrine
- Tizanidine
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