Schild plot
Schild plot is a graphical method used in pharmacology to study the effects of different drugs on biological systems. It was developed by the British pharmacologist G. A. B. Schild in the 1940s. The Schild plot is a useful tool for determining the potency of a drug and its possible interactions with other substances.
History[edit | edit source]
The Schild plot was first introduced by G. A. B. Schild in the 1940s. Schild was a British pharmacologist who made significant contributions to the field of receptor theory. His work on the Schild plot has been influential in the study of drug interactions and the development of new medications.
Methodology[edit | edit source]
The Schild plot is a type of dose-response curve that plots the logarithm of the concentration of an antagonist against the logarithm of the dose ratio minus one. The dose ratio is the ratio of the dose of an agonist that produces a specified response in the presence of an antagonist to the dose of the agonist that produces the same response in the absence of the antagonist.
The slope of the Schild plot gives the pA2 value, which is a measure of the potency of the antagonist. A slope of 1 indicates that the antagonist is competitive, while a slope different from 1 indicates that the antagonist is non-competitive.
Applications[edit | edit source]
Schild plots are widely used in pharmacology to study the effects of drugs on biological systems. They can be used to determine the potency of a drug, its possible interactions with other substances, and the nature of the drug-receptor interaction.
In addition to pharmacology, Schild plots are also used in other fields such as biochemistry and physiology to study the interactions between different biological molecules.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD