Drug discovery

From WikiMD's Wellnesspedia

Drug Discovery[edit | edit source]

Target Validation in Peptide Drug Discovery

Drug discovery is a crucial process in medicine, biotechnology, and pharmacology, involving the identification of new candidate medications. The journey from the inception of a new drug idea to its introduction to the market is complex, involving a myriad of scientific disciplines, including biology, chemistry, and pharmacology. This process has evolved significantly over time, from traditional remedies and serendipitous discoveries to sophisticated modern techniques.

Historical Overview[edit | edit source]

Structural Biology and Drug Discovery

Historically, drug discovery involved the identification of the active ingredients from traditional remedies or by serendipitous discoveries, such as the discovery of penicillin by Alexander Fleming in 1928. These methods relied heavily on natural substances and the observant nature of scientists and laypeople.

Modern Methods[edit | edit source]

With advancements in science and technology, drug discovery has become more systematic and targeted. The sequencing of the human genome and advances in molecular biology have transformed drug discovery into a more precise and efficient process.

High Throughput Screening (HTS)[edit | edit source]

Modern drug discovery often utilizes high throughput screening (HTS), a method that allows researchers to quickly conduct millions of chemical, genetic, or pharmacological tests. This process rapidly identifies active compounds, antibodies, or genes that modulate a particular biomolecular pathway.

Chemical Libraries and Screening[edit | edit source]

Chemical libraries, consisting of synthetic small molecules, natural products, or extracts, are screened against isolated biological targets or within intact cells or whole organisms to find substances with therapeutic potential. This approach, known as classical pharmacology, has been augmented by the availability of large compound libraries and the capability to screen thousands of compounds rapidly.

Targeted Drug Design[edit | edit source]

The process has also been enhanced by targeted drug design, including structure-based drug design (SBDD) and ligand-based drug design (LBDD), where the interaction between the drug and its biological target is studied in detail to design more effective and selective drugs.

Challenges and Future Directions[edit | edit source]

Despite technological advances, drug discovery faces challenges such as high costs, long timelines, and a high failure rate. Future directions aim at integrating artificial intelligence and machine learning to predict drug efficacy and safety profiles, thereby reducing the time and cost associated with drug development.

Significance[edit | edit source]

The significance of drug discovery lies in its potential to provide new treatments for diseases, improve the quality of life, and extend human lifespan. It remains a fundamental process in the development of new medicines, addressing unmet medical needs and contributing to global health advancements.

External Links[edit | edit source]

References[edit | edit source]

  • "The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs" - Book by Enrique Ravina.
  • "High Throughput Screening for Drug Discovery: Historical Perspectives and Future Directions" - Article in Journal of Biomolecular Screening.



Template:Med-stb


Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Admin, Kondreddy Naveen