Para-Methoxy-N-methylamphetamine

Para-Methoxy-N-methylamphetamine (PMMA), also known as 4-methoxy-N-methylamphetamine and commonly known as Red Mitsubishi, is a psychoactive drug of the phenethylamine and amphetamine chemical classes that is known to have been sold as a designer drug. It is a serotonin-norepinephrine-dopamine releasing agent (SNDRA) with additional monoamine oxidase inhibitor (MAOI) activity.

Chemistry

PMMA is a substituted amphetamine, a member of a diverse group of compounds including everything from antidepressants to decongestants. It is structurally similar to methamphetamine, differing by the addition of a methoxy group at the para position on the phenyl ring.

Pharmacology

PMMA acts as a selective serotonin releasing agent (SRA) with weak effects on dopamine and norepinephrine transporters. However, it is not as potent in its effects as other amphetamines, particularly methamphetamine. It also acts as a monoamine oxidase A inhibitor, and may potentially be used in the treatment of depression or anxiety.

Effects

The effects of PMMA are often compared to those of MDMA, but they are not identical. PMMA tends to produce more stimulant-like effects than MDMA, and is associated with less intense euphoria. The onset of effects is generally slow and effects can last for several hours.

Health Risks

PMMA is known to be more toxic than many other recreational drugs, particularly when taken in high doses. It can cause serious side effects such as hyperthermia, high blood pressure, rapid heart rate, and seizures. In severe cases, it can result in serotonin syndrome, a potentially life-threatening condition.

Legal Status

The legal status of PMMA varies by country. In many countries, including the United States, it is classified as a Schedule I drug under the Controlled Substances Act.

See Also

• Amphetamine
• Methamphetamine
• MDMA
• Serotonin syndrome