Benzphetamine

Benzphetamine

Benzphetamine is a stimulant that is used as an anorectic or appetite suppressant in the treatment of obesity. It is chemically related to amphetamines, which are a group of psychoactive drugs that stimulate the central nervous system and have effects on physical energy, mood, and appetite. Benzphetamine is marketed under various brand names, such as Didrex among others.

Medical Uses

Benzphetamine is primarily prescribed for the short-term management of obesity, alongside diet, exercise, and behavior modification. It is intended for use in individuals with a body mass index (BMI) that is significantly higher than what is considered healthy and who have not been able to lose weight with diet and exercise alone.

Pharmacology

Benzphetamine works by stimulating the release of norepinephrine and dopamine, two neurotransmitters that have a significant impact on hunger and satiety. By increasing the levels of these neurotransmitters, benzphetamine reduces appetite, leading to a decrease in food intake and an increase in energy expenditure. Unlike some other appetite suppressants, benzphetamine does not have a significant effect on serotonin levels.

Side Effects

The use of benzphetamine can lead to a range of side effects, some of which may be serious. Common side effects include insomnia, dry mouth, nausea, and increased heart rate. More severe side effects may include hypertension, heart palpitations, and psychosis. Due to its chemical similarity to amphetamines, there is also a risk of dependence and abuse.

Contraindications

Benzphetamine is contraindicated in individuals with a history of cardiovascular disease, hyperthyroidism, glaucoma, and drug abuse. It should also not be used in combination with other central nervous system stimulants or within 14 days of taking a monoamine oxidase inhibitor (MAOI).

Regulation

In many countries, benzphetamine is classified as a controlled substance due to its potential for abuse and dependence. Its use is regulated, and it is available only with a prescription from a licensed healthcare provider.

See Also

• Amphetamine
• Obesity
• Appetite suppressant
• Central nervous system stimulant

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