Phenylethanolamine

Phenylethanolamine is a natural monoamine alkaloid and trace amine, which acts as an adrenergic receptor agonist in mammals.

Chemistry

Phenylethanolamine is a beta-hydroxylated derivative of phenethylamine, and can also be viewed as a phenol derivative of norepinephrine. It is structurally similar to a number of plant alkaloids including ephedrine and cathinone.

Pharmacology

Phenylethanolamine acts as a nonselective agonist at the alpha-1 adrenergic receptor, alpha-2 adrenergic receptor, and beta adrenergic receptors. It does not possess the amine oxidase inhibitory properties of phenethylamine.

Biosynthesis

Phenylethanolamine can be synthesized in the laboratory by the reduction of 2-nitro-1-phenyl-ethanol, or by the hydrogenation of phenylacetonitrile followed by hydrolysis.

See also

• Phenethylamine
• Norepinephrine

Phenylethanolamine Resources
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