Para-Bromoamphetamine

Para-Bromoamphetamine (PBA), also known as 4-bromoamphetamine, is a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. It acts as a serotonin releasing agent and is known for its neurotoxicity in humans.

Chemistry

PBA is a substituted amphetamine, which means it is a derivative of amphetamine, a powerful stimulant. The chemical structure of PBA includes a phenyl group, an amine group, and a bromine atom, which is responsible for its name. The bromine atom is attached to the fourth carbon in the amphetamine backbone, hence the prefix 'para-' in its name.

Pharmacology

PBA acts primarily as a serotonin releasing agent (SRA). This means it induces the release of serotonin, a neurotransmitter that plays a key role in regulating mood, appetite, sleep, and other functions. PBA can also release other neurotransmitters such as dopamine and norepinephrine, but its effect on serotonin is most pronounced.

Effects

The effects of PBA can vary widely depending on the dose, the individual's physiology, and the context in which it is used. Some common effects reported by users include feelings of euphoria, increased energy, enhanced empathy and sociability, and altered perception. However, PBA can also cause a range of negative effects, including anxiety, paranoia, insomnia, and potentially severe neurotoxicity.

Neurotoxicity

PBA is known to be neurotoxic, meaning it can damage the brain. This is believed to be due to its ability to release large amounts of serotonin, which can lead to a depletion of this neurotransmitter and potentially cause damage to the neurons that produce it. The extent of this neurotoxicity and its long-term effects are still not fully understood.

Legal Status

The legal status of PBA varies by country. In many places, it is classified as a controlled substance due to its potential for abuse and its neurotoxic effects.

See Also

• Amphetamine
• Serotonin releasing agent
• Neurotoxicity