Oxilofrine

Oxilofrine (also known as methylsynephrine, hydroxyephrine, oxyephrine, and 4-HMP) is a stimulant compound. It is often used as an ingredient in dietary supplements but has been associated with adverse cardiovascular events in certain populations.

History

Oxilofrine was originally developed in the 1970s by the pharmaceutical company Boehringer Ingelheim. It was marketed as a pharmaceutical drug in Europe for the treatment of hypotension (low blood pressure). However, it was never approved for use in the United States by the Food and Drug Administration (FDA).

Use in Dietary Supplements

Despite not being approved for use in the United States, oxilofrine has been found in various dietary supplements. It is often marketed as a weight loss aid, energy booster, and performance enhancer. However, the FDA has issued warnings about the use of dietary supplements containing oxilofrine, stating that they are adulterated and illegal.

Health Risks

The use of oxilofrine has been associated with several health risks. These include increased heart rate and blood pressure, chest pain, cardiac arrest, and in some cases, death. The risk is particularly high in individuals with pre-existing cardiovascular conditions.

Legal Status

In many countries, including the United States, oxilofrine is considered a banned substance in athletic competitions. The World Anti-Doping Agency (WADA) includes oxilofrine on its list of prohibited substances. Athletes who test positive for oxilofrine can face sanctions, including disqualification and suspension.

See Also

• Dietary supplement
• Stimulant
• Food and Drug Administration
• World Anti-Doping Agency

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